Calmodulin antagonists also decreased the cytochrome p450 content of microsomes. Lipid peroxidation after ionizing irradiation leads to apoptosis and. Selenium represents an adjuvant that selectively sensitizes cancer cells to these treatments modalities, potentially by inducing lipid peroxidation. Leaf extract of moringa oleifera prevents ionizing. Vitamin e and vitamin c completely protected against uvb radiation induced lipid peroxidation p induced a vitamin e consumption of up to 100% in the stratum corneum and viable epidermis, and a vitamin c consumption of only 21% in the stratum corneum. The present study evaluated the hepatoprotective effect of aqueous ethanolic moringa oleifera leaf extract mole against radiationinduced oxidative stress, which is assessed in terms of inflammation and lipid peroxidation. Radiationinduced lipid peroxidation triggers ferroptosis and. We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for radiationinduced cancer cell death. Radiationinduced lipid peroxidation triggers ferroptosis and synergizes. Topical antioxidant vitamins c and e prevent uvbradiation. Inhibition of radiationinduced lipid peroxidation by curcumin in n20 saturated rat liver microsomes. It is the interaction of these radiationinduced free radicals with important biomolecules within the cell that is the basis of the cellular sensitivity to radiation.
Ionizing radiation track structure and the nature of induced biological effects ionizing radiation is classified as either electromagnetic or particulate. Pdf inhibition of radiationinduced lipid peroxidation. Pdf amelioration of ionizing radiation induced lipid peroxidation in. Pdf influence of ferulic acid on gammaradiation induced. Pdf antioxidant capabilities of scoparone, the component of artemisia scoparia and other medicinal plants, against lipid peroxidation induced by.
We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for. Radiation induced peroxidation and fragmentation of lipids in a model membrane. Swiss albino mice were administered mole 300 mgkg of body weight for 15 consecutive days before exposing them to a single dose of 5 gy of 60 co. Radiation induced lipid peroxidation in liposomes sciencedirect. Pdf scoparone inhibits ultraviolet radiationinduced lipid. Radiationinduced peroxidation and fragmentation of lipids. Lipid peroxidation is shown to have importance in understanding the modifications of radiation effects. Vitamin e and vitamin c completely protected against uvbradiationinduced lipid peroxidation p pdf 51 k pdf plus 97 k citing articles. Methylseleninic acid induces lipid peroxidation and radiation. Inhibition of radiation induced lipid peroxidation by tetrahydrocurcumin.
Modulation of radiation induced lipid peroxidation by phospholipase. Therefore, compounds that sensitize cancer cells to radiation via alternative cell death pathways are valuable. Ionizing radiationinduced metabolic oxidative stress and. Curcumin was incorporated into microsomes during ultracentrifugation. Pdf protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. Radiationinduced lipid peroxidation and membrane permeability. Antioxidant activity of capsaicin on radiationinduced. Ionizing radiation track structure and the nature of induced biological effects.
Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of dna repair and inhibition of apoptosis. Additional methods and supplemental figures and tables pdf. Request pdf radiation induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Ionizing radiation is classified as either electromagnetic or particulate.
We have studied the effect of ferrous ions on radiation induced lipid peroxidation. Antioxidant activity of capsaicin on radiationinduced oxidation of murine hepatic mitochondrial membrane preparation ramachandran gangabhagirathi,1 ravi joshi,2 1bioorganic division, 2radiation and photochemistry division, bhabha atomic research center, trombay, mumbai, india abstract. Effects of calmodulin antagonists on radiationinduced. Radiation induced peroxidative damage semantic scholar. Capsaicin is the major capsaicinoid in chili peppers and is widely used as a spice. Request pdf radiationinduced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Ionizing radiation is known to induce oxidative stress through generation of reactive oxygen species ros resulting in imbalance of the prooxidant and antioxidant activities ultimately resulting in cell death.
Radiationinduced lipid peroxidation triggers ferroptosis. Pdf protective effect of moringa oleifera leaf extract mole against radiation induced lipid peroxidation has been investigated. Protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. Inhibition of radiationinduced lipid peroxidation by. Efforts are made to show similarities between radiolytic and. Amelioration of ionizing radiation induced lipid peroxidation.
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